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KMID : 0360919700130030226
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Journal of the Korean Medical Association
1970 Volume.13 No. 3 p.226 ~ p.232
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EXPERIMENTAL STUDIES ON FROSTBITE:ITS TREATMENT AND PREVENTION
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禹泰河/Woo, Tae Ha
朴旭和/李正馥/Park, Wook Hwa/Lee, Jung Bok
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Abstract
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Experiments on treatment and prevention of frostbite were carried out in 1969.
Healthy albino rats weighing from 150 to 250gm for experimental frostbite and healthy young men for the measuring of peripheral blood flow were employed in this study.
In animal experiments, the distal 7cm of tail in rat was immersed directly into the solution of ether-carbon dioxide mixture which was consistently kept cooled to -20°C.
Various drugs were injected into rats intraperitoneally before or after the onset of frostbite, and gross observations concerning the color, ulceration and gangrene which might be developed on affected sites were made for seven days. A comparison was also performed between the rapid-and gradual-thawing in water on frozen tail of rats.
In human experiments, finger blood flow following immersion of finger into 6°C water for 30 minutes was measured for one month by using Strain Gauge Plethysmograph.
The results obtained are summarized as follows;
1. The pretreatment of rats with Vasculat, Niacin and Vitamin E effectively prevented the frostbite as compared to the non-treated controls, whereas Vitamin C was not effective.
2. In human subject, however, Vasculat or Vitamin E did not influence peripheral blood flow remarkably by plethysmograph.
3. The treatment of rats with Vasculat and Vitamin C markedly enhanced the healing of frostbite. However, administration of Vitamin E and Niacin, and the topical application of local protective ointment were not effective.
4. Theeffects of both rapid-and gradual-thawing methods were excellent for the treatment of the frostbite, and of these methods, the former was more superior to the latter.
From these findings, it is suggested that the rapid thawing in the early treatment of frostbite is the most useful treatment for the alleviation of frostbite.
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